Circadian clocks and hypertension: genetics and interactions.

O C Ikonomov, A C Shisheva, A G Stoynev
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Abstract

Recent advances in molecular genetics of circadian rhythms and hypertension led to the discovery of separate groups of genes implicated in their regulation. Importantly, the identification in both mammals and flies of 6 homologous circadian clock genes strongly indicates that the circadian period is controlled by an evolutionary conserved set of genes. Studies in familial and experimental hypertension reveal that elevated blood pressure is due to mutations in genes implicated in the function of the renin-angiotensin-aldosterone system. A chronobiologic approach to experimental hypertension indicates that hypertension can be associated with selectively inverted circadian rhythm of arterial pressure. Several lines of evidence suggest that the rostral hypothalamus is an area of central integration of the endogenous rhythmic and other regulatory influences that modulate the phase and amplitude of circadian arterial pressure rhythmicity. The combination of advanced molecular genetics and continuous blood pressure monitoring with chronobiologic assessment emerges as a fruitful approach in better understanding the pathogenesis of hypertension.

生理时钟和高血压:基因和相互作用。
最近在昼夜节律和高血压分子遗传学方面的进展导致发现了与它们的调节有关的不同的基因组。重要的是,在哺乳动物和果蝇中发现的6个同源生物钟基因强烈表明,昼夜节律周期是由一组进化保守的基因控制的。家族性和实验性高血压研究表明,高血压升高是由于与肾素-血管紧张素-醛固酮系统功能相关的基因突变所致。实验高血压的时间生物学方法表明,高血压可能与动脉压的选择性倒转昼夜节律有关。一些证据表明,下丘脑吻侧是内源性节律和其他调节影响的中心整合区域,这些影响调节昼夜动脉压力节律性的相位和幅度。先进的分子遗传学和持续血压监测与时间生物学评估相结合,是更好地了解高血压发病机制的有效方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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