[Effect of endothelin-1 injected into rostral ventrolateral medulla on cardiovascular responses in cats].

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-06-01

X L Yang, W J Fu, G X Hou, J G Chen

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Abstract

Aim: To study the effect of endothelin-1 (ET-1) in the rostral ventrolateral medulla (rVLM) on cardiovascular responses in cats.

Methods: The stereotatic technique and microinjection method were used.

Results: ET-1 (4 mumol.L-1 0.5 microL) microinjected into rVLM induced mean arterial pressure (MAP) increasing (3.7 +/- 1.3) kPa, heart rate (HR) accelerating (29 +/- 7) beats.min-1, and renal nerve activity (RNA) intensifying 45% +/- 10%. The effects were dose-dependent. Before and after bilateral vagotomy, there was no significant difference in the reaction of MAP, HR, and RNA. After intravenous injection with phentolamine (5 mg.kg-1, alpha-blocker), ET-1 did not induce significant change of MAP. ET-1 raised the content of peripheral plasma argipressin (Arg) from (12.4 +/- 6.5) to (70.3 +/- 24.2) ng.L-1 with radioimmunoassay, and showed a correlation with MAP changes. ET-1 induced heart rhythm disorder (HRhD) in acute myocardiac ischemia, the occur time of HRhD was (4.8 +/- 2.9) min, and the score was 4.4 +/- 1.6, and it was significantly different from control.

Conclusion: ET-1 microinjected into rVLM could involve with control regulation of cardiovascular and sympathetic nerve activity.

本刊更多论文

[内皮素-1注入猫吻侧腹外侧髓质对心血管反应的影响]。

目的:研究猫吻侧腹外侧髓质(rVLM)内皮素-1 (ET-1)对心血管反应的影响。方法:采用立体定向技术和显微注射法。结果:ET-1 (4 μ mol);L-1 0.5 microL)微注射rVLM诱导平均动脉压(MAP)升高(3.7 +/- 1.3)kPa，心率(HR)加速(29 +/- 7)次。min-1，肾神经活性(RNA)增强45%±10%。效果是剂量依赖性的。双侧迷走神经切断术前后，MAP、HR、RNA的反应差异无统计学意义。静脉注射酚妥拉明(5mg)。kg-1 (α受体阻滞剂)、ET-1未引起MAP的显著变化。ET-1使外周血浆Arg (Arg)含量从(12.4 +/- 6.5)提高到(70.3 +/- 24.2)ng。L-1与放射免疫测定，并显示与MAP变化相关。ET-1诱导的急性心肌缺血心律失常(HRhD)发生时间为(4.8 +/- 2.9)min，评分为4.4 +/- 1.6，与对照组比较差异有统计学意义。结论:ET-1微注射rVLM可能参与心血管和交感神经活动的调控。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zhongguo yao li xue bao = Acta pharmacologica Sinica

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