Ro 31-8220 inhibits release of interleukin-1 and interleukin-6 from mouse peritoneal macrophages induced by fibrin fibrinogen degradation products.

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-05-01

B Zhou, J P Zhang, Z L Hu, Y X Tan, D H Qian

引用次数: 0

Abstract

Aim: To study the effect of fibrin fibrinogen degradation products (FFDP) on release of interleukin-1 (IL-1) and interleukin-6 (IL-6) from mouse peritoneal macrophages, and the effect of a new selectively potent protein kinase C inhibitor Ro 31-8220 (Ro).

Methods: IL-1 and IL-6 activities were measured by thymocyte proliferation assay and B9 cell proliferation methyl thiazolyl tetrazolium (MTT) colorimetric method, respectively.

Results: Ro 0.01-1 mumol.L-1 obviously inhibited FFDP-induced release of IL-1 and IL-6 from mouse peritoneal macrophages.

Conclusion: Ro exerted inhibitory effects on FFDP-induced release of IL-1 and IL-6 in vitro.

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Ro 31-8220抑制纤维蛋白原降解产物诱导的小鼠腹腔巨噬细胞释放白细胞介素-1和白细胞介素-6。

目的:研究纤维蛋白纤维蛋白原降解产物(FFDP)对小鼠腹腔巨噬细胞中白细胞介素-1 (IL-1)和白细胞介素-6 (IL-6)释放的影响，以及一种新的选择性强效蛋白激酶C抑制剂Ro 31-8220 (Ro)的作用。方法:分别采用胸腺细胞增殖法和B9细胞增殖甲基噻唑四氮唑(MTT)比色法测定白细胞介素-1和白细胞介素-6的活性。结果:Ro 0.01-1 μ mol。L-1明显抑制ffdp诱导的小鼠腹腔巨噬细胞IL-1和IL-6的释放。结论:Ro对ffdp诱导的IL-1和IL-6的体外释放有抑制作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zhongguo yao li xue bao = Acta pharmacologica Sinica

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