Selective effects of alfuzosin and doxazosin with intraduodenal administration on urethral pressure of cats.

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-05-01

Z H Yang, L M Ren, Z J Wu, S X Fu, Y S Li

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Abstract

Aim: To observe the selective effects of alfuzosin (Alf) and doxazosin (Dox) on the urethral pressure by different administration routes.

Methods: The urethral pressure of the anesthetized cat was increased by electric stimulation of the hypogastric nerve. The different effects of Alf or Dox on the arterial blood pressure and urethral pressure between intraduodenal administration (i.d.) and intravenous infusion (i.v.) were compared.

Results: When the hypogastric nerve was stimulated by electric stimulation (10 Hz, 25 V), the ratios of ED20(BP)/ED50(UP) i.d. to ED20(BP)/ED50(UP) i.v. were 10.9:4.3 for Alf, and 3.1:2.1 for Dox. The reduction in urethral pressure induced by i.d. Alf was greater than that by i.v. Alf. Dox did not show any difference in its effects by 2 administration routes.

Conclusion: Intraduodenal administration of Alf, but not Dox, selectively decreased the urethral pressure elevated by electric stimulation. The uroselectivity of i.d. Alf was not due to the species difference in its bioavailability and biotransformation.

本刊更多论文

阿复唑星和多沙唑星十二指肠内给药对猫尿道压力的选择性影响。

目的:观察阿复唑嗪(Alf)和多沙唑嗪(Dox)在不同给药途径下对尿道压力的选择性影响。方法:采用电刺激下腹神经的方法提高麻醉猫的尿道压力。比较阿福多昔十二指肠内给药(i.d)和静脉滴注(i.v)对动脉血压和尿道压的影响。结果:10 Hz, 25 V电刺激下腹神经时，Alf的ED20(BP)/ED50(UP)比值与Dox的ED20(BP)/ED50(UP)比值分别为10.9:4.3和3.1:2.1。静脉滴注Alf引起的尿道压力下降幅度大于静脉滴注Alf。两种给药途径对Dox的影响均无差异。结论:al可选择性降低电刺激引起的尿道压力，而Dox不能。Alf的尿选择性不是由于其生物利用度和生物转化的物种差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zhongguo yao li xue bao = Acta pharmacologica Sinica

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