Inhibition of myocardial inward rectifier potassium current by propylbutyldopamine.

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-06-01

W Dun, R R Zhao, J G Li, B W Wu

引用次数: 0

Abstract

Aim: To study the effects of propylbutyldopamine (PBDA) on the inward rectifier potassium current (Ik1).

Methods: The quasi-steady state current-voltage relationship from the isolated guinea pig ventricular cells were measured using whole-cell patch-clamp techniques with a slow ramp depolarization (8 mV.s-1).

Results: PBDA 5, 50, and 100 mumol.L-1 concentration-dependently reduced the inward rectifier potassium current. PBDA blocked Ik1 in guinea pig ventricular cells. The effect of PBDA was not blocked by the selective dopamine D2-receptor blocker, domperidone.

Conclusion: PBDA inhibited Ik1 directly, independent of the dopamine D2-receptor.

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丙基丁基多巴胺对心肌内向整流钾电流的抑制作用。

目的:研究丙基丁基多巴胺(PBDA)对内向整流钾电流(Ik1)的影响。方法:采用慢速斜坡去极化(8 mv -s -1)全细胞膜片钳技术测量离体豚鼠心室细胞的准稳态电流-电压关系。结果:PBDA为5、50、100 μ mol。L-1浓度依赖性地减小了向内整流钾电流。PBDA阻断豚鼠心室细胞中的Ik1。PBDA的作用不被选择性多巴胺d2受体阻滞剂多潘立酮阻断。结论:PBDA直接抑制Ik1，不依赖于多巴胺d2受体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zhongguo yao li xue bao = Acta pharmacologica Sinica

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