Anti-arrhythmic effects of sophoridine and oxysophoridine.

H M Zhang, H Q Li
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Abstract

Aim: To compare the effects of oxysophoridine (Oxy) and sophoridine (Sop) on experimental arrhythmias and myocardial physiologic properties.

Methods: Arrhythmias were induced by drugs and myocardial ischemia. Physiologic properties were determined on isolated heart atria.

Results: Oxy 500 mg.kg-1 (1/6 LD50) decreased the incidence of ventricular arrhythmias induced by aconitine (P < 0.01), increased the threshold dose of ouabain-induced ventricular premature (VP, P < 0.05), ventricular tachycardia (VT, P < 0.05), ventricular fibrillation (VF, P < 0.01), and cardiac arrest, (P < 0.01). After i.v. Oxy 500 mg.kg-1 into the rats with ligation of left anterior descending coronary artery, the total numbers of ectopic beats were decreased (P < 0.05), the incidence of VF was lowered, and the duration of VT was shortened (P < 0.01). Oxy 250 mg.kg-1 (1/13 LD50) i.v. shortened the duration of arrhythmias induced by BaCl2 (P < 0.01) and delayed the onset of arrhythmias induced by chloroform-epinephrine (P < 0.05). Oxy produced dose-dependent positive inotropic effects in the isolated left atrial of guinea pigs, increased the concentration of epinephrine to elicit automaticity in left atria, decreased slightly the excitability, and prolonged the functional refractory period. Sop produced the similar effects on arrhythmias as Oxy.

Conclusion: Oxy produced the similar anti-arrhythmic effects as Sop did at the equivalent effective dose.

槐定和氧槐定的抗心律失常作用。
目的:比较槐定(Oxy)与槐定(Sop)对实验性心律失常及心肌生理特性的影响。方法:用药物和心肌缺血诱导心律失常。在离体心房上测定生理特性。结果:氧500mg;kg-1 (1/6 LD50)降低乌头碱致室性心律失常的发生率(P < 0.01),提高乌头碱致室性过早(VP, P < 0.05)、室性心动过速(VT, P < 0.05)、心室颤动(VF, P < 0.01)和心脏骤停的阈剂量(P < 0.01)。静脉注射奥施康定500毫克后。结扎左冠状动脉前降支后,异位搏动总数减少(P < 0.05),室性心动过速发生率降低,室性心动过速持续时间缩短(P < 0.01)。羟考酮250毫克。kg-1 (1/13 LD50)静脉注射可缩短BaCl2致心律失常的持续时间(P < 0.01),延迟氯仿肾上腺素致心律失常的发生时间(P < 0.05)。氧对豚鼠离体左心房产生剂量依赖性的正性肌力作用,使左心房肾上腺素浓度升高引起自动性,使左心房兴奋性轻微降低,延长功能不应期。Sop对心律失常的作用与oxyy相似。结论:在相同的有效剂量下,氧可产生与索普相似的抗心律失常作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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