Hypotensive effect of tenuifolic saponin and its mechanism.

W D Peng
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Abstract

Aim: To study the effect of tenuifolic saponin (TS) on arterial pressure.

Methods: Mean arterial pressure (MAP) was recorded from left carotid artery in rat which was anesthetized with urethane and then injected i.v. gtt with a transfusion of NaCl 0.15 mol.L-1. Systolic blood pressure (SBP) of conscious rat and renovascular hypertensive rat (RVHR) was measured by tail cuff method.

Results: TS 2, 4, 8 mg.kg-1 i.v., 20 and 40 mg.kg-1 i.g. reduced the MAP by 31%, 37%, 50%, 21%, and 31%, respectively. Bilateral vagotomy plus atropine (Atr) i.v., or pretreatment with diphenhydramine hydrochloride (Dip) failed to influence TS effect. Lack of effect of TS on carotid-occlusion-induced- or epinephrine (Epi)-induced-hypertensive response was found. SBP in conscious rat and RVHR was suppressed, highest by 38.0% and 26.8% at 60 and 90 min, maintaining at least 2 and 3 h, respectively, after i.g. TS 40 mg.kg-1.

Conclusion: TS reduced the arterial pressure, not related to vagus excitation, ganglionic blockade, and peripheral alpha-adrenergic-, M-cholinergic-, and H1-receptors.

茶叶皂苷的降压作用及其机制。
目的:研究茶叶皂苷(TS)对动脉压的影响。方法:用氨基甲酸乙酯麻醉大鼠,取左颈动脉平均动脉压(MAP),然后静脉注射氯化钠0.15 mol.L-1。用尾袖法测定清醒大鼠和肾血管性高血压大鼠的收缩压。结果:TS 2、4、8 mg;Kg-1静脉注射,20和40毫克。kg-1 kg分别降低了31%、37%、50%、21%和31%的MAP。双侧迷走神经切断术联合阿托品(Atr)静脉注射或盐酸苯海拉明(Dip)预处理均不能影响TS的效果。发现TS对颈动脉闭塞诱导或肾上腺素(Epi)诱导的高血压反应缺乏影响。清醒大鼠和RVHR的收缩压被抑制,在60和90分钟时最高,分别为38.0%和26.8%,在灌胃TS 40 mg.kg-1后分别维持至少2和3小时。结论:TS降低了动脉压,与迷走神经兴奋、神经节阻滞及外周α -肾上腺素能、m -胆碱能和h1受体无关。
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