Hepatitis viruses: their role in human cancer.

D W Bradley
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引用次数: 25

Abstract

Hepatitis B virus (HBV) has been shown to be linked causally to the development of hepatocellular carcinoma (HCC) in humans. One of the HBV gene products, the "X" protein, has been specifically implicated in the malignant transformation of hepatocytes; mutations in one or more of the HBV structural proteins have also been linked to HCC. HBV DNA may act as an insertional mutagen in the myc family of genes. Mutations within the pre-core and core promoter regions of HBV-DNA have also been associated with the development of HCC. Patients chronically infected with hepatitis C virus (HCV) often develop cirrhosis; a significant proportion of these patients progress to HCC. Although numerous genotypes of HCV exist, type 1b is most often associated with the eventual development of HCC in chronically infected patients. The molecular mechanisms for the malignant transformation of hepatocytes by HCV have not been elucidated.

肝炎病毒:它们在人类癌症中的作用
乙型肝炎病毒(HBV)已被证明与人类肝细胞癌(HCC)的发展有因果关系。HBV基因产物之一“X”蛋白已被证实与肝细胞的恶性转化有关;一种或多种HBV结构蛋白的突变也与HCC有关。HBV DNA可能在myc基因家族中作为插入性突变原。HBV-DNA前核和核心启动子区域的突变也与HCC的发生有关。慢性丙型肝炎病毒(HCV)感染的患者常发展为肝硬化;这些患者中有很大一部分进展为HCC。尽管存在多种HCV基因型,但1b型最常与慢性感染患者的HCC最终发展相关。HCV对肝细胞恶性转化的分子机制尚未阐明。
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