Long-term cyclosporin continuation rates in rheumatoid arthritis patients.

Abstract

Objective: To evaluate the continuation rate of cyclosporin therapy in rheumatoid arthritis patients followed for at least three years.

Methods: Retrospective medical chart review of rheumatoid arthritis patients on cyclosporin. Treatment efficacy was assessed based on a visual analog scale pain score, Ritchie's articular index, and Lee's functional index. Nonparametric Kaplan-Meier survival curves were used to evaluate continuation rates.

Results: 24 cyclosporin-treated patients with a mean age of 58 years and a mean disease duration of ten years were included in the study; 87% had received three second-line drugs prior to cyclosporin. Mean cyclosporin treatment duration was 28 months (range, 1-103 months). Overall cyclosporin continuation rates were 75% after four months and 50% after 36 months. Toxicity and inefficacy caused 33% and 13% of cyclosporin discontinuations, respectively.

Conclusion: The continuation rate of cyclosporin was satisfactory and similar to that reported for other second-line drugs.