Participation of M1 receptors in NO pathway in cat ileum.

N Kortezova, L Shikova, M Papasova
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Abstract

Electrical field stimulation (EFS) elicited two types of responses from longitudinal muscle strips of the distal cat ileum: contraction at switching on the stimulation (in 62% of the strips) and inhibition of the phasic contractions at switching on the stimulation followed by contraction in 38% of the strips. In all strips the muscarinic acetylcholine subtype M1-receptor agonist (4-Hydroxy-2-butynyl)-1-trimethylammonium-m-chlorocarbanilate chloride (McN-A-343) increased the tone and amplitude of the spontaneous contractions. On this background EFS elicited an inhibition of the phasic contractions at switching on the stimulation followed by contraction. Blockade of nitric oxide (NO)-synthase by Nw-nitro-L-arginine (L-NNA) transformed the inhibitory response into contraction and this transformation was partly overcome by L-arginine. The results suggest that presynaptically situated M1 receptors are involved in the NO pathway.

M1受体在猫回肠NO通路中的参与。
电场刺激(EFS)引起猫回肠远端纵肌条的两种类型的反应:在打开刺激时收缩(62%的条带)和在打开刺激时抑制相性收缩,随后收缩的条带占38%。在所有条带中,毒蕈碱乙酰胆碱亚型m1受体激动剂(4-羟基-2-丁基)-1-三甲基铵-m-氯氨基甲酸盐(McN-A-343)增加了自发收缩的张力和幅度。在此背景下,电刺激引起了在打开刺激后紧接收缩时的相性收缩抑制。nw -硝基- l -精氨酸(L-NNA)阻断一氧化氮(NO)合酶,将抑制反应转化为收缩,l -精氨酸部分克服了这种转化。结果表明位于突触前的M1受体参与NO通路。
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