Behavioral changes as a result of dotarizine or flunarizine influence on dopaminergic neurotransmission in the striatum.

V D Petkov, B Petkova
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Abstract

In experiments on rats, we studied the changes in stereotypy induced by apomorphine (2.5 mg/kg i.p.) or amphetamine (2 mg/kg i.p.) and in haloperidol (1 mg/kg i.p.) catalepsy in rats treated with dotarizine (25 mg/kg orally), flunarizine (25 mg/kg) or vehicle for 10 days. Dotarizine did not induce any significant changes in the intensity and duration of apomorphine- or amphetamine-induced stereotypy nor in haloperidol-induced catalepsy. The flunarizine-induced changes in the behavioral effects of apomorphine, amphetamine and haloperidol suggest the decrease of striatal dopaminergic neurotransmission, whereby the risk of occurrence of extrapyramidal side effects of the drug when used in clinical practice. Dotarizine is not associated with such a risk.

多他嗪或氟桂利嗪对纹状体多巴胺能神经传递的影响所导致的行为改变。
在大鼠实验中,我们研究了阿波啡(2.5 mg/kg i.p)或安非他明(2 mg/kg i.p)和氟哌啶醇(1 mg/kg i.p)对多他嗪(25 mg/kg口服)、氟桂利嗪(25 mg/kg口服)或载药治疗10天大鼠的刻板印象的变化。Dotarizine在阿波啡或安非他明诱导的刻板印象的强度和持续时间以及氟哌啶醇诱导的猝睡中没有引起任何显著变化。氟桂利嗪引起的阿波啡、安非他明和氟哌啶醇行为效应的改变提示纹状体多巴胺能神经传递减少,从而在临床应用时增加了该药发生锥体外系副作用的风险。Dotarizine与这种风险无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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