Regulation of the plasminogen activator system in the ovary.

Y X Liu
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引用次数: 33

Abstract

Extracellular matrix (ECM) not only provides a structural support for the organism, but also actively conducts cell-to-cell signal transduction and regulates cell proliferation, migration, development and metabolism. The targeted ECM degradation generated by plasminogen activator (PA) and regulated by plasminogen activator inhibitor (PAI) is, therefore, an event that affects a wide variety of physiological and pathological processes. The ovary is the best model to study the regulation and function of extracellular proteolysis mediated by multicomponents like the PA system. Studies carried out over the past 10 years in a number of laboratories have elucidated some of the biochemical events related to the function and regulation of the PA system in the ovary: hormone-induced proteolytic activity provided by tissue-type PA(tPA) and modulated by PAI-1 in the preovulatory follicles is responsible for a controlled and directed proteolysis leading to rupture of selected follicles during ovulation, whereas the coordinated expression of urokinase-type PA (uPA) and PAI-1 in the early growing follicle may be important in ECM degradation during cell proliferation and migration; the PA system may also play a role in the control of corpus luteum (CL) development through an autocrine or paracrine mechanism. Increase in tPA and PAI-1 expression in CL at a later stage is well correlated with a sharp decrease in CL progesterone production, while the increase in uPA mRNA levels and activity in the early stage of CL development is correlated with an increase in progesterone secretion.

卵巢纤溶酶原激活剂系统的调节。
细胞外基质(Extracellular matrix, ECM)不仅为生物体提供结构支持,还积极进行细胞间的信号转导,调节细胞的增殖、迁移、发育和代谢。因此,由纤溶酶原激活剂(PA)产生并受纤溶酶原激活剂抑制剂(PAI)调控的靶向ECM降解是一个影响多种生理和病理过程的事件。卵巢是研究PA系统等多组分介导的细胞外蛋白水解调控及其功能的最佳模型。在过去的10年里,在许多实验室进行的研究已经阐明了一些与卵巢中PA系统的功能和调节有关的生化事件:在排卵前卵泡中,由组织型PA(tPA)提供并由PAI-1调节的激素诱导的蛋白水解活性负责控制和指导蛋白水解,导致排卵期间选定的卵泡破裂,而尿激酶型PA(uPA)和PAI-1在早期生长卵泡中的协调表达可能在细胞增殖和迁移过程中的ECM降解中起重要作用;PA系统也可能通过自分泌或旁分泌机制在控制黄体(CL)的发展中发挥作用。晚期CL中tPA和PAI-1表达的增加与CL孕酮产量的急剧下降密切相关,而CL发展早期uPA mRNA水平和活性的增加与孕酮分泌的增加密切相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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