Effects of near-ultraviolet (UV-A) light on melatonin biosynthesis in vertebrate pineal gland.

Biological signals and receptors Pub Date : 1999-01-01 DOI:10.1159/000014570

J B Zawilska, J Rosiak, J Z Nowak

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引用次数: 9

Abstract

The effects of near-ultraviolet (UV-A) irradiation on nocturnal activity of serotonin N-acetyltransferase (NAT; a key regulatory enzyme in melatonin biosynthesis) in the pineal gland of the rat and chick were investigated. Exposure of the animals to UV-A during the 4th or 5th hour of the dark phase of the 12:12 h light-dark (LD) cycle suppressed the night-driven NAT activity in a time-dependent manner, the effects being generally more pronounced in rats than in chicks. The UV-A-evoked suppression of the nocturnal NAT activity was completely restored within 2 h (chicks) or 3 h (rats) in animals which, after irradiation, were returned to darkness. When a short UV-A pulse was applied to the animals after midnight, it induced a decrease in the enzyme activity in both species; yet, the effect was readily reversible only in chicks. The results presented here, as well as other data, demonstrate that UV-A light is a powerful signal affecting the pineal melatonin-generating system both in mammals and avians, and that the involved mechanisms may differ in the tested species.

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近紫外线(UV-A)光对脊椎动物松果体褪黑激素生物合成的影响。

近紫外线(UV-A)照射对夜间血清素n -乙酰转移酶(NAT)活性的影响对大鼠和雏鸡松果体中褪黑素生物合成的关键调控酶进行了研究。在12:12 h光-暗循环的黑暗阶段的第4或第5小时暴露于UV-A，以一种时间依赖性的方式抑制夜间驱动的NAT活性，这种影响在大鼠中比在雏鸡中更为明显。紫外线诱发的夜间NAT活性的抑制在2 h(雏鸡)或3 h(大鼠)内完全恢复，照射后返回黑暗。当在午夜之后对这些动物施加短的UV-A脉冲时，它会导致两种动物的酶活性下降;然而，这种效应只有在雏鸟身上才容易逆转。本文的研究结果以及其他数据表明，UV-A光是影响哺乳动物和鸟类松果体褪黑激素生成系统的强大信号，所涉及的机制可能在被测试物种中有所不同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biological signals and receptors

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