Values for urinary beta 2-microglobulin and N-acetyl-beta-D-glucosaminidase in normal healthy infants.

Acta paediatrica Japonica : Overseas edition Pub Date : 1998-10-01 DOI:10.1111/j.1442-200x.1998.tb01961.x

M Nishida, H Kawakatsu, H Komatsu, K Ishiwari, M Tamai, K Tsunamoto, Y Kasubuchi, T Sawada

{"title":"Values for urinary beta 2-microglobulin and N-acetyl-beta-D-glucosaminidase in normal healthy infants.","authors":"M Nishida, H Kawakatsu, H Komatsu, K Ishiwari, M Tamai, K Tsunamoto, Y Kasubuchi, T Sawada","doi":"10.1111/j.1442-200x.1998.tb01961.x","DOIUrl":null,"url":null,"abstract":"Background: Measuring urinary beta 2 microglobin (B2M) and N-acetyl-beta-D-glucosaminidase (NAG) excretion is widely used as a valuable clinical tool in assessing renal tubular lesions. However, few data are available on normal values for urinary excretion of B2M and NAG in infancy.Methods: Urinary B2M and NAG were measured in healthy infants. The logarithmic values of urinary B2M, NAG, B2M/creatinine ratio and NAG/creatinine ratio were distributed almost normally and reference ranges were calculated from the logarithms of the observed values.Results: The levels of urinary B2M and B2M/creatinine ratio were highest in the 1-month-old group, followed by a decrease during the first 3 months. Urinary B2M excretions in the 3-month-old group showed rather lower levels than those of the 12-month-old and 36-month-old groups. Although urinary NAG excretions were almost constant throughout all groups, urinary NAG/creatinine ratio decreased gradually until 3 years of age.Conclusions: We suggest that these reference ranges are of importance in evaluating tubular damage due to a variety of renal diseases in infancy.","PeriodicalId":76975,"journal":{"name":"Acta paediatrica Japonica : Overseas edition","volume":"40 5","pages":"424-6"},"PeriodicalIF":0.0000,"publicationDate":"1998-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1442-200x.1998.tb01961.x","citationCount":"11","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta paediatrica Japonica : Overseas edition","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/j.1442-200x.1998.tb01961.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 11

Abstract

Background: Measuring urinary beta 2 microglobin (B2M) and N-acetyl-beta-D-glucosaminidase (NAG) excretion is widely used as a valuable clinical tool in assessing renal tubular lesions. However, few data are available on normal values for urinary excretion of B2M and NAG in infancy.

Methods: Urinary B2M and NAG were measured in healthy infants. The logarithmic values of urinary B2M, NAG, B2M/creatinine ratio and NAG/creatinine ratio were distributed almost normally and reference ranges were calculated from the logarithms of the observed values.

Results: The levels of urinary B2M and B2M/creatinine ratio were highest in the 1-month-old group, followed by a decrease during the first 3 months. Urinary B2M excretions in the 3-month-old group showed rather lower levels than those of the 12-month-old and 36-month-old groups. Although urinary NAG excretions were almost constant throughout all groups, urinary NAG/creatinine ratio decreased gradually until 3 years of age.

Conclusions: We suggest that these reference ranges are of importance in evaluating tubular damage due to a variety of renal diseases in infancy.

查看原文本刊更多论文

正常健康婴儿尿β 2微球蛋白和n -乙酰- β - d -氨基葡萄糖酶的测定值。

背景:检测尿β 2微珠蛋白(B2M)和n -乙酰- β - d -氨基葡萄糖酶(NAG)的排泄量被广泛用作评估肾小管病变的有价值的临床工具。然而，关于婴儿尿中B2M和NAG排泄正常值的数据很少。方法:对健康婴儿进行尿B2M、NAG测定。尿B2M、NAG、B2M/肌酐比值、NAG/肌酐比值的对数分布基本符合正态分布，参考范围由观测值的对数计算。结果:尿B2M水平和B2M/肌酐比值在1月龄组最高，在前3月龄组下降。与12个月和36个月大的婴儿相比，3个月大的婴儿尿液中B2M的水平要低得多。虽然尿NAG排泄在所有组中几乎不变，但尿NAG/肌酐比值逐渐下降，直到3岁。结论:我们认为这些参考范围对评估婴儿时期各种肾脏疾病引起的肾小管损害具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Acta paediatrica Japonica : Overseas edition

自引率

0.00%

发文量