Improving source reconstructions by combining bioelectric and biomagnetic data

Manfred Fuchs , Michael Wagner , Hans-Aloys Wischmann , Thomas Köhler , Annette Theißen , Ralf Drenckhahn , Helmut Buchner
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引用次数: 232

Abstract

Objectives: A framework for combining bioelectric and biomagnetic data is presented. The data are transformed to signal-to-noise ratios and reconstruction algorithms utilizing a new regularization approach are introduced.

Methods: Extensive simulations are carried out for 19 different EEG and MEG montages with radial and tangential test dipoles at different eccentricities and noise levels. The methods are verified by real SEP/SEF measurements. A common realistic volume conductor is used and the less-well-known in-vivo conductivities are matched by calibration to the magnetic data. Single equivalent dipole fits as well as spatiotemporal source models are presented for single and combined modality evaluations and overlaid to anatomic MR images.

Results: Normalized sensitivity and dipole resolution profiles of these acquisition systems are derived from these synthetic data. The methods are verified by simultaneously measured somasensory data.

Conclusions: Superior spatial resolution of the combined data studies is revealed, which is due to the complementary nature of both modalities and the increased number of sensors. a better understanding of the underlying neironal processes can be acheived, since an improved differentiation between quasi-tangential and quasi-radial sources is possible.

结合生物电和生物磁数据改进震源重建
目的:提出一种结合生物电和生物磁数据的框架。将数据转换为信噪比,并介绍了利用新的正则化方法的重构算法。方法:采用径向偶极子和切向偶极子在不同偏心率和噪声水平下对19种不同的EEG和MEG蒙太奇进行了广泛的模拟。用实际SEP/SEF测量结果验证了方法的正确性。一种常见的实际体积导体被使用,不太为人所知的体内电导率通过校准磁数据来匹配。单一等效偶极子拟合以及时空源模型提出了单一和组合模态评估和叠加到解剖磁共振图像。结果:从这些合成数据中得出了这些采集系统的归一化灵敏度和偶极子分辨率曲线。通过体感数据的同步测量验证了方法的正确性。结论:由于两种模式的互补性和传感器数量的增加,揭示了组合数据研究的优越空间分辨率。由于准切向和准径向源之间的改进区分是可能的,因此可以更好地理解潜在的神经元过程。
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