Efficacy and cross reactivity of Thai green pit viper antivenom among venoms of Trimeresurus species in Thailand and Japan.

Journal of natural toxins Pub Date : 1998-06-01
N Pakmanee, O Khow, N Wongtongkam, T Omori-Satoh, V Sitprija
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引用次数: 0

Abstract

The efficacy of the Thai green pit viper antivenom to neutralize lethal, hemorrhagic, and enzyme activities of Trimeresurus venoms was examined using venoms of Trimeresurus albolabris, T. macrops, and T. flavoviridis (Japanese Habu). Antivenom against Japanese Habu venom was also used to study immunological cross reactivity among Trimeresurus venoms. Thai green pit viper antivenom was comparably effective to Habu antivenom to neutralize all activities. Distinct cross neutralization was demonstrated indicating the presence of genus specific protection by Thai and Japanese Trimeresurus antivenoms. Results of immunoblotting analyses indicated that Thai and Japanese Trimeresurus venoms contain many cross-reactive protein components.

泰国绿坑蝰蛇抗蛇毒血清在泰国和日本Trimeresurus种毒液中的疗效和交叉反应性。
用泰国绿穴蝰蛇、大毒蛇和黄毒蛇毒(日本Habu)的毒液检测了泰国绿穴蝰蛇抗蛇毒血清中和三毒蛇毒的致死性、出血性和酶活性。同时,用日本毒抗蛇毒血清研究了三叶草毒液的免疫交叉反应性。泰国绿坑蝰蛇抗蛇毒血清与哈布抗蛇毒血清具有相当的中和作用。结果表明,泰国和日本的Trimeresurus抗蛇毒血清具有属特异性保护作用。免疫印迹分析结果表明,泰国和日本Trimeresurus毒液含有许多交叉反应蛋白成分。
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