{"title":"Lipid modifications and membrane targeting of G alpha.","authors":"P B Wedegaertner","doi":"10.1159/000014538","DOIUrl":null,"url":null,"abstract":"<p><p>G protein alpha-subunits (G alpha) undergo palmitoylation and/or myristoylation. This review will focus on new insights into the function and regulation of these fatty acid modifications of G alpha. Most importantly, I will examine lipid modifications of G alpha in the context of a two-signal model for membrane attachment, discuss recent advances in the identification of palmitoyl transferases, and highlight several controversial issues in this field.</p>","PeriodicalId":79565,"journal":{"name":"Biological signals and receptors","volume":"7 2","pages":"125-35"},"PeriodicalIF":0.0000,"publicationDate":"1998-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000014538","citationCount":"62","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biological signals and receptors","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000014538","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 62
Abstract
G protein alpha-subunits (G alpha) undergo palmitoylation and/or myristoylation. This review will focus on new insights into the function and regulation of these fatty acid modifications of G alpha. Most importantly, I will examine lipid modifications of G alpha in the context of a two-signal model for membrane attachment, discuss recent advances in the identification of palmitoyl transferases, and highlight several controversial issues in this field.
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