Assessment of proliferative activity, DNA values and some clinicopathologic parameters in mesenchymal tumors. Immunohistochemical and flow cytometric study.
A Niezabitowski, J Ryś, A Roessner, B Lackowska, R Schneider-Stock, A Gruchała, A Wasilewska, A Kruczak, I Swiatkiewicz, A Sokolowski, W Szklarski, A Jaszcz, A Stelmach
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引用次数: 0
Abstract
Clinicopathologic parameters of 70 consecutive mesenchymal tumors from 63 patients were evaluated. In all these cases, the DNA content was analyzed by flow cytometry, and the expression of proliferative antigen MIB1 and p53 protein was assessed by immunohistochemistry. Our study verified the prognostic usefulness of proliferative indicators, above all MIB1-index, which strongly correlated with tumor grade and independently influenced overall survival.
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