Pancreatic islet cell hyperplasia associated with experimental ulcerative colitis in rats.

Abstract

Ulcerative colitis in Buffalo rats was induced by acetic acid introduced into sigmoid colon. In specimens of the colon and head of the pancreas obtained via laparotomy after seven-day colitis ulcerosa and simultaneously the pancreatic islet cell hyperplasia were histologically observed. Further investigations, especially immunological studies, of these amazing findings are necessary to elucidate the mechanism of the abore relationship.