Suprachiasmatic nuclei lesions eliminate the group circadian rhythm of systolic arterial pressure but not of heart rate in rats.

A G Stoynev, P D Penev, O C Ikonomov, F Halberg
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Abstract

The aim of this study was to evaluate the participation of the suprachiasmatic nuclei (SCN) in the generation and synchronization of cardiovascular rhythms. Seven sham-operated and 11 SCN-lesioned animals maintained under 12/12 hr light/dark cycle were used. Systolic arterial pressure (SAP) and heart rate (HR) were measured indirectly during 24-hour periods at 3-4 hour intervals. The data were analyzed using individual and group cosinor rhythmometry and Fourier analysis. A circadian rhythm of water intake was not detected in animals with successful SCN lesions. A reduction of the double amplitude/MESOR ratio for the 24-hour component of drinking rhythm in the SCN-lesioned rats was observed. After SCN lesions the group 24-hour rhythm of SAP was eliminated while a significant group circadian rhythm for HR was detected. The individual amplitude/MESOR ratios for the 24-, 12-, 8- and 6-hour periodic components of SAP and HR in the lesioned rats showed no marked differences as compared with controls. The generation and entrainment of circadian variations in HR is probably not dependent on the integrity of SCN in rats. The SCN may participate in the entrainment of the circadian rhythm of SAP. The combination of completely abolished (water intake) and persisting (heart rate) rhythms further supports that the circadian regulatory system consists of a network of multiple oscillators.

视交叉上核损伤可消除大鼠收缩压昼夜节律,但不影响心率昼夜节律。
本研究的目的是评估视交叉上核(SCN)在心血管节律的产生和同步中的参与。7只假手术动物和11只scn损伤动物维持在12/12小时明暗循环下。在24小时内,每隔3-4小时间接测量收缩压(SAP)和心率(HR)。数据分析采用个体和群体余弦节律和傅立叶分析。在成功的SCN病变动物中未检测到水摄入的昼夜节律。观察到scn损伤大鼠24小时饮酒节律双振幅/MESOR比值降低。SCN病变后,SAP的24小时节律被消除,而HR的昼夜节律被检测到。损伤大鼠SAP和HR的24小时、12小时、8小时和6小时周期分量的个体振幅/MESOR比值与对照组相比无显著差异。大鼠HR中昼夜节律变化的产生和携带可能不依赖于SCN的完整性。SCN可能参与SAP昼夜节律的调节。完全取消(水摄入)和持续(心率)节律的结合进一步支持昼夜节律调节系统由多个振荡器组成的网络。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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