Effects of cholecystokinine on the gallbladder motility: interaction with somatostatin and vasoactive intestinal peptide.

K Milenov, A Rakovska, R Kalfin
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Abstract

Recent years have seen an increase in the information concerning the mechanisms of action of brain-gut neuropeptides (cholecystokinin (CCK), vasoactive intestinal peptide (VIP), somatostatin (SS)) on the biliary tract motility. This article is intended to extend our knowledge of the problem and based on our recent studies. Researchers and students interested in an historical overview of the subject, as well as in the information on the physiology and pharmacology of biliary smooth muscle are referred to earlier reviews (Ryan, 1981, 1987). The article focuses on the involvement of cholinergic mechanisms in the action of CCK, SOM and VIP on the gallbladder motility under in vivo and in vitro conditions. Some species differences in the responses of the gallbladder to CCK, VIP and ACh have also been described. Furthermore, new data about the interactions between CCK, SOM and VIP in the regulation of the gallbladder motility are presented.

胆囊收缩素对胆囊运动的影响:与生长抑素和血管活性肠肽的相互作用。
近年来,脑肠神经肽(cholecystokinin, CCK)、血管活性肠肽(vasoactive intestinal peptide, VIP)、生长抑素(somatostatin, SS)对胆道运动的作用机制研究越来越多。本文旨在扩展我们对这个问题的认识,并以我们最近的研究为基础。研究人员和学生对该学科的历史概况以及胆道平滑肌的生理学和药理学信息感兴趣,可参考早期的综述(Ryan, 1981,1987)。本文就CCK、SOM和VIP在体内和体外条件下影响胆囊运动的胆碱能机制进行了综述。胆囊对CCK、VIP和ACh反应的一些物种差异也被描述。此外,还报道了CCK、SOM和VIP在胆囊运动调节中的相互作用的新数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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