beta-Adrenoceptor agonists-induced desensitization in rat trachea.

Abstract

The development and the characteristics of beta-adrenoceptor agonists-induced desensitization in rat trachea were studied. Tracheal strips were contracted with carbachol and cumulative concentration-response curves for various beta-adrenoceptor agonists were constructed before and after 30-min incubation either with the same beta-adrenoceptor agonist or with another beta-adrenoceptor agonist. Some problems of the in vitro desensitization in rat trachea were also considered.