[The influence of the blood microcirculatory bed on the cellular immune response in the regional lymph nodes of a cancerous tumor (an immunohistochemical and ultrastructural study)].

Abstract

Immunohistochemical, ultrastructural, morphological and morphometric techniques as well as monoclonal antibodies to F VIII R:Ag endotheliocytes, CD2 and CD3 T-lymphocytes, CD1 and CD10 T-lymphoblasts, CD4 T helpers, CD8 and CD30 T-killers and activated lymphocytes were used to study blood microcirculation relationship to cellular immunity in lymph nodes regional to malignant tumor. It was established that on the one hand there was early activation of cellular immune reactions with high level of cytotoxic T-cells and enhanced lymphocyte recirculation via postcapillary venules, on the other side at later stages changes in the vascular wall and circulatory disorders develop in line with deposition of intra- and extravascular fibrin. This impedes lymphocyte recirculation and leads to a cut in the number of T-effectors enabling prevention of metastatic spread to the lymph nodes.