{"title":"[Prognostic significance of the activity of nucleolar organizer regions in megakaryocytes from patients with acute lymphoblastic leukemia].","authors":"A V Koloskov, N N Mamaev","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Bone marrow films from 20 patients with acute lymphoblastic leukemia (ALL) and 40 patients with acute nonlymphoblastic leukemia (ANLL) were investigated using Ag-NOR staining. The control group comprised 12 donors. The activity of nucleolar organizer regions (NOR) in the whole population of megakaryocytes (MK) and in groups of MK with 1-3, 4-6, 7 and more lobules per nucleus was assessed. The division into groups made it possible to judge about NOR activity in MK with different ploidy. The MK with both high ploidy and high NOR activity in residual megakaryocytopoiesis in patients with ALL are associated with good response to chemotherapy and complete remission, whereas these with low ploidy and low NOR activity suggest poor prognosis. In patients with ANLL no stable correlation between NOR activity and prognosis was found.</p>","PeriodicalId":50427,"journal":{"name":"Gematologiya I Transfuziologiya","volume":"41 1","pages":"23-5"},"PeriodicalIF":0.2000,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gematologiya I Transfuziologiya","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Bone marrow films from 20 patients with acute lymphoblastic leukemia (ALL) and 40 patients with acute nonlymphoblastic leukemia (ANLL) were investigated using Ag-NOR staining. The control group comprised 12 donors. The activity of nucleolar organizer regions (NOR) in the whole population of megakaryocytes (MK) and in groups of MK with 1-3, 4-6, 7 and more lobules per nucleus was assessed. The division into groups made it possible to judge about NOR activity in MK with different ploidy. The MK with both high ploidy and high NOR activity in residual megakaryocytopoiesis in patients with ALL are associated with good response to chemotherapy and complete remission, whereas these with low ploidy and low NOR activity suggest poor prognosis. In patients with ANLL no stable correlation between NOR activity and prognosis was found.
期刊介绍：
The journal publishes original theoretical and clinical studies, lectures, reviews, and practical notes concerning various problems of hematology and clinical and industrial transfusion. The journal provides information on the etiology, pathogenesis, diagnosis and treatment of blood disorders as well as on related non-hematological conditions (internal diseases, poisoning, exposure to ionizing radiation etc.).
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