[Value of several hormone indicators and cyclic nucleotides in the assessment and prognosis of resistance to acute hypoxia during operator activities].

Abstract

A study was performed in which 16 healthy volunteers, aged 25-40 years, worked in a two-dimensional tracking simulator and breathed a mixture containing 9-12% oxygen. This led to a higher incretion of cortisol, insulin, somatotropin, a greater renal excretion of epinephrine, norepinephrine, and a higher content of cAMP in lymphocytes, plasma and urine. The subjects with a higher insulin in plasma and renal excretion of catecholamines showed a longer time of tolerance to the above exposure which varied from 50 to 120 min. The high tolerance was combined with a greater activity of the sympathoadrenal system, incretion of cortisol and cAMP in lymphocytes. A significant correlation was demonstrated between cAMP in the above environments both before and after exposure.