[Dynamics of prostaglandin contents and several indicators of lipid metabolism in man exposed to prolonged hypokinesis].

Abstract

Nine healthy test subjects divided into Group A and Group B were bed rested (with the head down at -5 degrees) for 370 days. Group A subjects exercised from the beginning of the study while Group B subjects began exercising only 120 days after. During the study prostaglandins PGE and PGF2 alpha in serum and fatty acids in serum and erythrocyte membranes were measured. The lipid concentration in erythrocyte membranes decreased during the study and returned to the norm at a final stage and after the study. However, changes in higher fatty acids and a dramatic decline of prostaglandin give evidence for serious alterations of lipid metabolism at the cellular level.