Zinc and magnesium serum levels in patients with benign prostatic hyperplasia (BPH) before and after prazosin therapy.

S Dutkiewicz
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Abstract

In 32 patients with benign prostatic hyperplasia (BPH) serum levels of zinc and magnesium were studied before and after prazosin therapy with (Minipress-Pfizer), 4 mg daily. Following cessation of therapy a slight increase in Zn levels was observed, i.e. from 99.79 to 103.29 micrograms/dl, whereas Mg levels did not change significantly (1.95 and 1.94 mg/dl, respectively). In comparison with other organs, the human prostate is characterized by high Zn and Mg content. In BPH the Zn levels are increased. They are markedly decreased in carcinoma of the prostate and in prostatitis [4, 5]. Zn and Mg play an important role as catalysts in various enzymatic reactions. It has been postulated that changes in concentrations of these two elements are parallel [6]. Kvist has found that Zn imparts resistance to detergent-induced decondensation of spermatozoon nuclear chromatin. The effect was more pronounced with higher Zn concentrations in a buffer fluid. Other bivalent cations were found to be ineffective in stabilizing nuclear chromatin under such conditions. A possible role for seminal zinc in prevention of the reduction of disulfide cross-links and nuclear decondensation was postulated [2]. Zinc also plays an important role in protein synthesis. Zinc ions inhibit androgen metabolism in the prostate. Physiologic Zn serum levels are equal to or above 90 micrograms/dl [4, 6]. Magnesium, unlike zinc, is uniformly distributed within different areas of the gland. In BPH, both normal and increased Mg levels in the prostate have been reported [6]. Mg plays an important role as an activator of enzymes (phosphatases) involved in ATP metabolism, thus affecting both katabolic and anabolic processes.(ABSTRACT TRUNCATED AT 250 WORDS)

吡唑嗪治疗前后良性前列腺增生(BPH)患者血清锌、镁水平的变化。
对32例良性前列腺增生(BPH)患者进行吡唑嗪(Minipress-Pfizer)每日4mg治疗前后血清锌、镁水平的研究。停止治疗后,观察到锌水平略有增加,即从99.79微克/分升到103.29微克/分升,而Mg水平没有显著变化(分别为1.95和1.94毫克/分升)。与其他器官相比,人的前列腺具有锌、镁含量高的特点。在BPH中,锌水平升高。它们在前列腺癌和前列腺炎中显著降低[4,5]。锌和镁在各种酶促反应中起着重要的催化剂作用。据推测,这两种元素的浓度变化是平行的[6]。Kvist发现锌对洗涤剂诱导的精子核染色质去浓缩具有抗性。缓冲液中锌浓度越高,效果越明显。在这种条件下,其他二价阳离子在稳定核染色质方面是无效的。假设种子锌在防止二硫交联的减少和核去浓缩方面可能起作用[2]。锌在蛋白质合成中也起着重要作用。锌离子抑制前列腺雄激素代谢。生理性血清锌水平等于或高于90微克/分升[4,6]。镁与锌不同,它均匀地分布在腺体的不同区域。在BPH中,前列腺中正常和升高的Mg水平均有报道[6]。Mg作为参与ATP代谢的酶(磷酸酶)的激活剂起着重要作用,从而影响分解代谢和合成代谢过程。(摘要删节250字)
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