Effect of evening versus morning benazepril on 24-hour blood pressure: a comparative study with continuous intraarterial monitoring.

P Palatini, L Mos, M Motolese, P Mormino, M Del Torre, L Varotto, E Pavan, A C Pessina
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Abstract

In a single-blind, in-patient, crossover study, the influence on the circadian blood pressure (BP) profile of the 9:00 a.m. versus the 9:00 p.m. acute administration of a single dose of benazepril 10 mg, a new angiotensin-converting-enzyme inhibitor, was assessed in 10 hypertensive patients by means of 24-hour intraarterial ambulatory BP monitoring. Mean 24-hour BP for the three treatments (placebo, benazepril a.m., benazepril p.m.) were 155/93, 131/83 and 138/86 mmHg, respectively. No significant differences between the two benazepril schedules were found in terms of either 24-hour or day-time and night-time mean BP values. However, hourly averages showed that benazepril a.m. had a more sustained antihypertensive effect than benazepril p.m., where a loss of efficacy was observed 19 hours after the administration. BP responses to static and dynamic exercise and to cold pressor test were unchanged after both benazepril schedules, as were BP peaks. These results demonstrate that acute benazepril administration markedly reduces systolic and diastolic BP. The morning administration is preferable because it more effectively covers the whole 24 hours than an evening dose.

晚上与早晨服用苯那普利对24小时血压的影响:一项连续动脉内监测的比较研究。
在一项单盲住院交叉研究中,通过24小时动脉内动态血压监测,评估了上午9点与晚上9点急性给药单剂量苯那普利10mg(一种新型血管紧张素转换酶抑制剂)对10例高血压患者昼夜节律血压(BP)谱的影响。三种治疗(安慰剂、贝那普利上午、贝那普利下午)的平均24小时血压分别为155/ 93,131 /83和138/86 mmHg。在24小时或白天和夜间的平均血压值方面,两种贝那普利方案没有发现显著差异。然而,小时平均值显示,上午服用贝那普利的降压效果比下午服用贝那普利的降压效果更持久,而下午服用贝那普利的降压效果在服用19小时后就消失了。两种苯那普利治疗后,静态、动态运动和冷压试验的血压反应没有变化,血压峰值也没有变化。这些结果表明,急性贝那普利可显著降低收缩压和舒张压。早晨给药是可取的,因为它比晚上给药更有效地覆盖整个24小时。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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