[DNCG (acecromol) and ketotifen (Zatofug) in treatment of children with bronchial asthma].

Abstract

In an open clinical study, 80 children and adolescents of 12 months to 20 years of age suffering from asthma bronchiale were treated for a minimum of 8 weeks with DNCG (acecromol) or ketotifen (Zatofug) or with both drugs. Both under the treatment with DNCG and with ketotifen the overall disease pattern was improved with a large proportion of the patients and the concurrent adjuvant medication with prednisolone and/or aminophyllin could be markedly reduced or in some cases discontinued altogether. Both substances appear to be comparable as far as the therapy result is concerned; however, the range of application of ketotifen is wider due to its additional antihistaminic action and oral administration, e.g. in case of concomitant urticaria or food allergy.