Relationship between cytokines and leukotriene B4 in sepsis.

H Nakae, S Endo, K Inada, T Takakuwa, T Kasai, M Yoshida
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Abstract

To clarify the relationship between cytokines and arachidonic acid metabolites, we measured tumor necrosis factor (TNF-alpha), interleukin 8 (IL-8), and leukotriene B4 (LTB4). The subjects consisted of 30 patients with sepsis. The results were compared between patients who died (Group A) and those who survived (Group B). All TNF-alpha, IL-8, and LTB4 levels were significantly higher in Group A than in Group B, reflecting the severity of the disease. The LTB4 levels were significantly correlated with the TNF-alpha level and the IL-8 level. These results suggest that inflammatory cytokines, excessively produced due to inflammatory reactions, stimulate as a mediator the release of arachidonic acid, increasing LTB4 production.

细胞因子与白三烯B4在脓毒症中的关系。
为了阐明细胞因子与花生四烯酸代谢物之间的关系,我们测量了肿瘤坏死因子(tnf - α)、白细胞介素8 (IL-8)和白三烯B4 (LTB4)。研究对象为30例脓毒症患者。将死亡患者(A组)和存活患者(B组)的结果进行比较。A组的tnf - α、IL-8和LTB4水平均显著高于B组,反映了疾病的严重程度。LTB4水平与tnf - α和IL-8水平显著相关。这些结果表明,由于炎症反应而过量产生的炎症细胞因子作为介质刺激花生四烯酸的释放,增加LTB4的产生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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