[The genotype of CYP2E1 and liver-derived serum enzymes].

Abstract

We determined the genotypes of the CYP2E1 loci of Japanese alcoholics with or without liver dysfunction to investigate the relationship between CYP2E1 and the susceptibility to alcoholic liver-injury. In the alcoholics (DSM-III-R) with a liver dysfunction, there was a significant relationship between the serum concentration of a liver-derived serum enzyme LAP and the C2 allele of CYP2E1.