Late degradation tissue response to poly(L-lactide) bone plates and screws.

IF 12.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Biomaterials Pub Date : 1995-01-01 DOI:10.1016/0142-9612(95)91092-d

J E Bergsma, W C de Bruijn, F R Rozema, R R Bos, G Boering

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引用次数: 818

Abstract

Patients with fractures of the zygomatic bone were treated with high molecular weight poly(L-lactic) acid (PLLA) bone plates and screws. Three years after implantation four patients returned to our department with a swelling at the site of implantation. At the recall of the remaining patients we found an identical type of swelling after the same implantation period. To investigate the nature of the tissue reaction, eight patients were reoperated for the removal of the swelling. The implantation period of the PLLA material varied from 3.3 to 5.7 years. Microscopic evaluation and molecular weight measurements were performed. The excised material showed remnants of degraded PLLA material surrounded by a dense fibrous capsule. Ultrastructural investigation showed crystal-like PLLA material internalized by various cells. The results of this investigation suggest that the PLLA material slowly degrades into particles with a high crystallinity. The intra- and extracellular degradation rate of these particles is very low. After 5.7 years of implantation, these particles were still not fully resorbed.

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晚期退化组织对聚l -丙交酯骨板和螺钉的反应。

颧骨骨折患者采用高分子量聚乳酸(PLLA)骨板和螺钉治疗。植入三年后，4例患者因植入部位肿胀而返回我科。在回忆其余患者时，我们发现同一植入期后出现相同类型的肿胀。为了研究组织反应的性质，8例患者再次手术切除肿胀。PLLA材料的植入周期从3.3年到5.7年不等。进行了显微评价和分子量测定。切除的材料显示被致密纤维囊包围的降解PLLA材料残余物。超微结构研究显示晶体状PLLA材料被各种细胞内化。本研究结果表明，pla材料缓慢降解成具有高结晶度的颗粒。这些颗粒在细胞内和细胞外的降解率非常低。植入5.7年后，这些颗粒仍未完全被吸收。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomaterials 工程技术-材料科学：生物材料

CiteScore

26.00

自引率

2.90%

发文量

565

审稿时长

46 days

期刊介绍： Biomaterials is an international journal covering the science and clinical application of biomaterials. A biomaterial is now defined as a substance that has been engineered to take a form which, alone or as part of a complex system, is used to direct, by control of interactions with components of living systems, the course of any therapeutic or diagnostic procedure. It is the aim of the journal to provide a peer-reviewed forum for the publication of original papers and authoritative review and opinion papers dealing with the most important issues facing the use of biomaterials in clinical practice. The scope of the journal covers the wide range of physical, biological and chemical sciences that underpin the design of biomaterials and the clinical disciplines in which they are used. These sciences include polymer synthesis and characterization, drug and gene vector design, the biology of the host response, immunology and toxicology and self assembly at the nanoscale. Clinical applications include the therapies of medical technology and regenerative medicine in all clinical disciplines, and diagnostic systems that reply on innovative contrast and sensing agents. The journal is relevant to areas such as cancer diagnosis and therapy, implantable devices, drug delivery systems, gene vectors, bionanotechnology and tissue engineering.