Antibody humanization predicted by computer graphic analysis.

American biotechnology laboratory Pub Date : 1995-08-01
K Ramnarayan, E Skaletsky
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引用次数: 0

Abstract

Humanized antibodies continue to be evaluated in clinical trials, and each trial will yield valuable information for the design of the next generation of humanized antibodies. More attention will be given to the use of antibody fragments and the selection of human antibody specificities from phage libraries for human antibody therapeutics. Computer graphic analysis and molecular modeling of antibody structures will continue to be invaluable for predicting structural modifications for humanization of antibodies and for extracting structural information from antigen binding sites that can ultimately lead to small molecule therapeutics.

用计算机图形分析预测抗体人源化。
人源化抗体继续在临床试验中进行评估,每次试验都将为下一代人源化抗体的设计提供有价值的信息。抗体片段的使用和噬菌体文库中人类抗体特异性的选择将被更多地关注于人类抗体治疗。计算机图形分析和抗体结构的分子建模对于预测抗体人源化的结构修饰和从抗原结合位点提取结构信息,最终导致小分子治疗,将继续是无价的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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