S S Kirzon, R V Lenskaia, T I Tkacheva, E N Aref'eva, Ia Ia Lutskaia, E A Mamedova
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引用次数: 0
Abstract
The previously established fact of low activity of Ca, Mg-dependent endonucleolysis of cell nucleus DNA in lymphoproliferative diseases (CME-activity) brought the authors to study intranuclear characteristics of lymphoid cells in childhood acute lymphoblastic leukemia (ALL). The intensity of DNA-endonucleolysis was measured in 0.7% agarose gel using electrophoresis. Peripheral blood and bone marrow samples from 13 untreated ALL patients and 23 children in remission were examined. The age of the patients ranged from 4 to 14 years. CME-activity before treatment appeared to be 2-10 times less than normal in 8 out of 13 patients. In bone marrow cell nuclei CME-activity was universally reduced 3-20-fold. In ALL remission endonuclease activity in blood and bone marrow cells returned to normal.
期刊介绍：
The journal publishes original theoretical and clinical studies, lectures, reviews, and practical notes concerning various problems of hematology and clinical and industrial transfusion. The journal provides information on the etiology, pathogenesis, diagnosis and treatment of blood disorders as well as on related non-hematological conditions (internal diseases, poisoning, exposure to ionizing radiation etc.).
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