[Restoration of hematopoiesis following allo- and automyelotransplantation in patients with hemoblastosis].

Abstract

The early stages of hemopoiesis repair as indicated by histologic examinations of trephine biopsy specimens (visual assessment and morphometry) are characterized in 39 patients with hemoblastoses, 33 of these with acute leukemia, 4 with chronic myeloleukemia, and 2 with lymphoblastic lymphosarcoma, following transplantation of allogeneic (n = 19), syngeneic (n = 5), and autologous (n = 15) bone marrow after conditioning with cyclophosphamide plus total radiation exposure in 27 patients and myelosan with cyclophosphamide in 12 ones. Hemopoiesis repair was found to be slower after autologous transplantation of bone marrow than after allogeneic transplantation and in patients following conditioning with cyclophosphamide and total irradiation in comparison with those pretreated with myelosan and cyclophosphamide. Patients' age over 25, diagnosis of the disease more than 12 months before transplantation, and variant of leukemia (nonlymphoblastic) were the factors exerting negative influence on the rate of hemopoiesis recovery.