M A Frenkel', N N Tupitsyn, T D Rudinskaia, V S Poltoranina, N B Lebedeva, M A Volkova, G I Kaletin
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引用次数: 0
Abstract
Expression of new Mab D11 on blood and bone marrow cells was investigated in 85 hemoblastosis patients. In normals, antigen D11 is expressed on some monocytes and all tissue macrophages. D11 was noted on lymphoblasts of 5 out of 10 cases with B-cell ALL and of 1 case in B-lymphoid blast crisis of chronic myeloid leukemia. In T-ALL, ANLL, non-Hodgkin's lymphomas in leukemization stage, hairy cell leukemia and chronic lymphoid leukemia the cells were nonresponsive to Mab D11. Unlike D11 which have round nuclei, lymphoblasts D11+ have folded nuclei and more pronounced cytoplasmic basophilia. There were both B and myeloid antigens on D11+ blasts. ALL D11+ patients had extramedullary foci, more suppressed granulocytic and thrombocytic components of hemopoiesis, shorter remissions than those with ALL D11-.
研究了85例造血增生患者血液和骨髓细胞中new Mab D11的表达。在正常情况下，抗原D11在一些单核细胞和所有组织巨噬细胞上表达。10例b细胞ALL患者中有5例和1例慢性髓性白血病b细胞危象患者的淋巴母细胞均检测到D11。在T-ALL、ANLL、白血病期非霍奇金淋巴瘤、毛细胞白血病和慢性淋巴样白血病中，细胞对单抗D11无反应。与圆核的D11不同，D11+淋巴细胞细胞核折叠，胞浆嗜碱性更明显。D11+细胞既有B抗原，也有髓系抗原。ALL D11+患者有髓外灶，造血中粒细胞和血小板成分受到更多抑制，缓解时间比ALL D11-患者短。
期刊介绍：
The journal publishes original theoretical and clinical studies, lectures, reviews, and practical notes concerning various problems of hematology and clinical and industrial transfusion. The journal provides information on the etiology, pathogenesis, diagnosis and treatment of blood disorders as well as on related non-hematological conditions (internal diseases, poisoning, exposure to ionizing radiation etc.).
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