A neutral sugar is responsible for serovar specificity of the antigenic determinant of Leptospira interrogans serovar canicola.

IF 0.4 4区农林科学 Q4 VETERINARY SCIENCES

Japanese Journal of Veterinary Research Pub Date : 1994-08-01

H Kashiwase, E Ono, R Yanagawa, Y Shimizu, H Kida

引用次数: 0

Abstract

To provide information on the chemical structures of antigenic determinants of leptospira, glycolipids of Leptospira interrogans serovar canicola strain Hond Utrecht IV (Ut-IV) and its antigenic variant selected in the presence of a serovar-specific monoclonal antibody were compared physicochemically. Gas-liquid chromatography-mass spectrometry analysis revealed that the glycolipid of Ut-IV contained 6 neutral sugar species; rhamnose, mannose, galactose, glucose, and unknown sugars III and IV, in addition to unknown sugars I and II that had been previously reported. On the other hand, the glycolipid of the variant lacked unknown sugar III, suggesting that this sugar is responsible for the serovar-specific antigenic determinant.

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一种中性糖对疑问钩端螺旋体血清型canicola抗原决定因子的血清特异性负责。

为了了解钩端螺旋体抗原决定因子的化学结构，在血清特异性单克隆抗体的作用下，对钩端螺旋体血清canicola Hond Utrecht IV株(Ut-IV)及其抗原变异株的糖脂进行了理化比较。气液色谱-质谱分析发现Ut-IV的糖脂中含有6种中性糖;鼠李糖，甘露糖，半乳糖，葡萄糖，未知糖III和IV，以及之前报道的未知糖I和II。另一方面，该变体的糖脂缺乏未知的糖III，这表明这种糖负责血清特异性抗原决定因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese Journal of Veterinary Research 农林科学-兽医学

CiteScore

1.00

自引率

0.00%

发文量

审稿时长

>36 weeks

期刊介绍： The Japanese Journal of Veterinary Research (JJVR) quarterly publishes peer-reviewed articles on all aspects of veterinary science. JJVR was originally published as a “University Journal” of veterinary science at Hokkaido University from more than 60 years ago. Currently, JJVR, is Japan’s leading scientific veterinary journal, and provides valuable information for the development of veterinary science by welcoming contributions from researchers worldwide. JJVR offers online submission for Regular Papers, Short Communications, and Review Articles that are unpublished and not being considered for publication elsewhere. Research areas include: Anatomy, Physiology, Biochemistry, Pharmacology, Microbiology, Infectious diseases, Parasitology, Laboratory Animal Science and Medicine, Internal Medicine, Surgery, Pathology, Theriogenology, Molecular Medicine, Public Health, Radiation Biology, Toxicology, Wildlife Biology and Medicine, Veterinary Hygiene, The other fields related to veterinary science.