[Adjuvant therapy of soft-tissue sarcomas: intraoperative--postoperative chemotherapy (author's transl)].

Abstract

3 mg of 3,4 benzpyrene were injected subcutaneously into the neck of 90 male SD rats. After 140 days, fibrosarcomas developed in the same place. At a size of 2--4 g, the tumor was completely removed according to surgical rules. One group was operated only, whereas the other groups were subjected to operation and intraoperative or postoperative chemotherapy (CYVADIC). It could be shown that operation in combination with a postoperative chemotherapy significantly lengthens the survival period and reduces local recurrences, contrary to operation alone. Chemotherapy started intraoperatively does not increase the survival period. The considerable toxicity is an essential factor limiting the therapeutic process, although it reduces local recurrences. We think that the tumors of chemical genesis present a suitable model in addition to the graft tumors in testing new treatment forms against malignant diseases.