Time-synchronized activation of lipolysis and fatty acids reacylation by bradykinin and angiotensin II in the perfused rabbit kidney.

Abstract

BK and AII administered to the isolated perfused rabbit kidney activate two sequential enzymatic processes: 1) a selective release of the PG precursor, AA with concomitant, partial conversion of arachidonate to PGE2. 2) Activation of a reacylation process which leads to decreased release of all fatty acids in the perfusate. There is a lag time of approximately 1 min between initial activation of the arachidonate-specific deacylation reaction that is coupled to PG generation, and subsequent activation of the reacylation process.