Pharmacological basis of dosage form of two antimalarials: chloroquine and mepacrine.

E Minker, Z Matejka
{"title":"Pharmacological basis of dosage form of two antimalarials: chloroquine and mepacrine.","authors":"E Minker,&nbsp;Z Matejka","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Chloroquine and mepacrine appear in the stomach wall and inhibit gastric emptying in the rat after oral or parenteral administration. Measuring their concentration in the stomach wall, it was found that it depended upon on the route of application. A smaller proportion of a given dose accumulated in the stomach wall when chloroquine and mepacrine were introduced by avoiding the stomach. The side effect of the two drugs, the inhibition of gastric motility, could be minimized by not only parenteral but also duodenal administration; the latter could be realized by enteric-coated tablets.</p>","PeriodicalId":7049,"journal":{"name":"Acta physiologica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta physiologica Academiae Scientiarum Hungaricae","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Chloroquine and mepacrine appear in the stomach wall and inhibit gastric emptying in the rat after oral or parenteral administration. Measuring their concentration in the stomach wall, it was found that it depended upon on the route of application. A smaller proportion of a given dose accumulated in the stomach wall when chloroquine and mepacrine were introduced by avoiding the stomach. The side effect of the two drugs, the inhibition of gastric motility, could be minimized by not only parenteral but also duodenal administration; the latter could be realized by enteric-coated tablets.

氯喹和甲哌辛两种抗疟药剂型的药理学基础。
口服或肠外给药后,氯喹和甲哌辛出现在胃壁,抑制胃排空。测定其在胃壁的浓度,发现其与施用途径有关。当氯喹和甲哌辛避开胃进入时,在给定剂量的胃壁中积累的比例较小。这两种药物的副作用,即抑制胃运动,可以通过肠外和十二指肠给药来最小化;后者可通过肠溶片实现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信