Effect of cholecystokinin antiserum on the brain monoamine content in rats.

Abstract

The effects of intracerebroventricular administration of cholecystokinin (CCK) antiserum )specific for COOH-terminal four amino acids) of CCK were tested in three dilutions on the dopamine (DA), norepinephrine (NE) and serotonin (5-HT) contents of the hypothalamus, amygdala, septum, striatum and cerebral cortex in rats 24 h following application. CCK antiserum decreased the DA and NE contents in the hypothalamus, mesencephalon, amygdala and septum, while it increased the DA content and decreased the NE content of the striatum. It had a slight effect on the 5-HT contents of the amygdala, septum and striatum.