An explanation for the S-phase specificity of the cytotoxicity of protein synthesis inhibitors

D.M. Woodcock, J.K. Adams, I.A. Cooper
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引用次数: 1

Abstract

A pulse of the protein synthesis inhibitor cycloheximide is shown to induce chromosome aberrations in cultured cells of human origin. These aberrations do not appear until in excess of 12 hr after the pulse and their appearance coincides with the time when cells which had been in S-phase at the time of the cycloheximide pulse reach mitosis. We suggest that the reason why the protein synthesis inhibitor cycloheximide has previously been reported not to induce chromosome aberrations is due to the long delay of cells with damaged chromosomes in reaching mitosis.

解释蛋白质合成抑制剂的细胞毒性的s期特异性
蛋白质合成抑制剂环己亚胺的脉冲显示诱导染色体畸变的培养细胞的人类来源。这些畸变直到脉冲后超过12小时才出现,它们的出现与在环己亚胺脉冲时处于s期的细胞达到有丝分裂的时间一致。我们认为,以前报道的蛋白质合成抑制剂环己亚胺不诱导染色体畸变的原因是由于染色体受损的细胞达到有丝分裂的时间较长。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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