[Influence of thioridazine on cognitive, psychomotor, and reaction performance in patients with dysthymic-depressive syndrome (author's transl)].

Abstract

We examined the influence of thioridazine (2 x 200 mg/d for 14 days) on cognitive (d 2-cancellation test, digit symbol substitution task), psychomotor (aiming, visual coordination as screwdriving test) as well as simple- and choice-reaction measurements in 16 in-patients suffering from dysthymic-depressive syndrome. The different thioridazine serum levels and the intelligence quotients of the patients were used as criteria of stratification. In this way we demonstrated differentiated impairments or improvements of the human performance. Such differences would have been masked by a more global evaluation and interpretation.