Poly(amino ester)s as an emerging synthetic biodegradable polymer platform: Recent developments and future trends

IF 26 1区化学 Q1 POLYMER SCIENCE

Progress in Polymer Science Pub Date : 2023-01-01 DOI:10.1016/j.progpolymsci.2022.101634

Xin Wang , Zhengbiao Zhang , Nikos Hadjichristidis

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引用次数: 4

Abstract

Poly(amino ester)s (PAEs) refer to a class of synthetic polymers characterized by repeating units in the backbone having tertiary amines and ester bonds, and bringing together the inherent biodegradability of polyesters and the rich tunable functionalities provided by tertiary amines. The presence of tertiary amines allows the introduction of various pendant groups, leading to diverse PAE material and properties, such as biodegradability, biocompatibility, water-solubility, stimulus-responsiveness (pH or temperature), etc. To date, PAEs are evolving into a new class of biodegradable polymer materials independent of aliphatic polyesters and have been widely used in various biomedical fields, such as gene delivery, drug delivery, bioimaging agents, etc. In addition, a new family of PAEs, namely N-acylated PAEs, with the same pendant carbonyl groups as poly(2-oxazoline)s, is expected to develop into new biopolymer platforms similar to polypeptoids and polyoxazolines. This review comprehensively summarizes the synthesis methods of PAEs, including polycondensation (PCD), Michael addition polymerization (MAP), spontaneous zwitterionic copolymerization (SZWIP), and ring-opening polymerization (ROP).

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聚(氨基酯)作为一种新兴的合成生物可降解聚合物平台:最新进展和未来趋势

聚氨基酯(PAEs)是一类合成聚合物，其特征是在主链中具有叔胺和酯键的重复单元，并将聚酯固有的生物降解性和叔胺提供的丰富可调功能结合在一起。叔胺的存在允许引入各种悬垂基团，从而产生不同的PAE材料和性能，如生物可降解性、生物相容性、水溶性、刺激反应性(pH或温度)等。PAEs是一种独立于脂肪族聚酯的新型生物可降解高分子材料，已广泛应用于基因传递、药物传递、生物显像剂等生物医学领域。此外，一个新的PAEs家族，即n -酰化PAEs，与聚(2-恶唑啉)s具有相同的挂链羰基，有望发展成为类似于多肽和多恶唑啉的新的生物聚合物平台。综述了PAEs的合成方法，包括缩聚法(PCD)、Michael加成聚合法(MAP)、自发两性离子共聚法(SZWIP)和开环聚合法(ROP)。

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来源期刊

Progress in Polymer Science 化学-高分子科学

CiteScore

48.70

自引率

1.10%

发文量

审稿时长

38 days

期刊介绍： Progress in Polymer Science is a journal that publishes state-of-the-art overview articles in the field of polymer science and engineering. These articles are written by internationally recognized authorities in the discipline, making it a valuable resource for staying up-to-date with the latest developments in this rapidly growing field. The journal serves as a link between original articles, innovations published in patents, and the most current knowledge of technology. It covers a wide range of topics within the traditional fields of polymer science, including chemistry, physics, and engineering involving polymers. Additionally, it explores interdisciplinary developing fields such as functional and specialty polymers, biomaterials, polymers in drug delivery, polymers in electronic applications, composites, conducting polymers, liquid crystalline materials, and the interphases between polymers and ceramics. The journal also highlights new fabrication techniques that are making significant contributions to the field. The subject areas covered by Progress in Polymer Science include biomaterials, materials chemistry, organic chemistry, polymers and plastics, surfaces, coatings and films, and nanotechnology. The journal is indexed and abstracted in various databases, including Materials Science Citation Index, Chemical Abstracts, Engineering Index, Current Contents, FIZ Karlsruhe, Scopus, and INSPEC.