Sequential intraperitoneal administration of nitroprusside in patients maintained on peritoneal dialysis.

E Riambau, J Lloveras, J Aubía, J Masramón, C García, M A Orfila, M Llorach
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引用次数: 5

Abstract

Clinical studies were made in order to determine the effects of intraperitoneal nitroprusside on the peritoneal clearances according to different frequencies of drug administration. An important increase of urea and creatinine clearances with 3.75 mg of nitroprusside per liter of dialysis solution was observed. The maximum effects were observed after four consecutive exchanges with the drug; its effects were maintained all through the peritoneal dialysis session and in some cases increased when alternative series of four exchanges with and without drug were carried on. The significative higher increase of the big solutes clearances suggests a vasodilator action of nitroprusside which should be also reflected on an increase of the middle size molecules clearances. Clinical tolerance was excellent and the blood pressure variations were negligible.

维持腹膜透析的病人按序腹腔注射硝普塞。
根据给药频率的不同,进行了临床研究,以确定硝普塞腹腔内对腹膜清除率的影响。观察到每升透析液中加入3.75 mg硝普塞可显著增加尿素和肌酐清除率。在连续四次服用该药后观察到最大的效果;在整个腹膜透析过程中,其效果一直保持不变,在某些情况下,当有和没有药物的四次交替交换进行时,其效果有所增加。大溶质间隙的显著增加表明硝普苷具有血管扩张作用,这也反映在中等大小分子间隙的增加上。临床耐受性良好,血压变化可以忽略不计。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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