Effect of bile acids on the biliary excretion of amaranth and the respiration of liver mitochondria.

Z Gregus, F Varga, E Fischer
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引用次数: 0

Abstract

The effects of lithocholic acid (LCA), chenodeoxycholic acid (CDCA), deoxycholic acid (DOCA), cholic acid (CA) and dehydrocholic acid (DHCA) on the biliary excretion of amaranth (AM) in rats and on the respiration of isolated liver mitochondria were investigated. Bile acids diminished the biliary excretion of AM, and in vitro they enhanced the state 4 mitochondrial respiration and inhibited DNP- and ADP-stimulated oxygen consumption. The ID50 values (mumol/kg i.v.) and I50 concentrations (X 10(-5) M) of the bile acids for inhibiting AM excretion and ADP-stimulated mitochondrial respiration, respectively, were as follows: for LCA 16 and 3.3, for CDCA 160 and 24, for DOCA 230 and 31, for CA 680 and 105, and for DHCA 700 and 260. LCA, CDCA and DOCA inhibited the biliary excretion of AM uncompetitively. It is concluded that the toxic effect of LCA, CDCA and DOCA on mitochondria might play a role in their inhibitory action on the biliary transport of AM.

胆汁酸对苋菜胆汁排泄及肝脏线粒体呼吸的影响。
研究了石胆酸(LCA)、鹅去氧胆酸(CDCA)、去氧胆酸(DOCA)、胆酸(CA)和去氢胆酸(DHCA)对苋菜大鼠胆汁排泄及离体肝线粒体呼吸的影响。胆汁酸可减少AM的胆汁排泄,并在体外增强线粒体呼吸状态,抑制DNP和adp刺激的耗氧量。抑制AM排泄和adp刺激的线粒体呼吸的胆汁酸的ID50值(mumol/kg i.v)和I50浓度(x10 (-5) M)分别为:lca16和3.3、cdca160和24、doca230和31、ca680和105、dhca700和260。LCA、CDCA和DOCA对AM的胆汁排泄无竞争性抑制作用。综上所述,LCA、CDCA和DOCA对线粒体的毒性作用可能与它们抑制AM胆道转运有关。
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