[Pathogenesis and hemodynamic significance of veno-arterial reaction in diabetic microcirculation disorders].

Acta biologica et medica Germanica Pub Date : 1982-01-01
S Kobylinski
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Abstract

In human diabetes mellitus, functional microangiopathy starts with venule dilatation, the cause of which is unknown. The results of comparative measurements of animals with alloxan diabetes verify also an increase in the arterio-venous calibre relation. As studied vital-microscopically, these alterations are due to venule congestion and passive dilatation as a consequence or red cell aggregation and an increase in the viscosity of blood. The increase of the flow resistance on the postcapillary side depends only on rheological but not on nervous-humoral factors, which leads by means of a veno-arterial reaction to increased constrictions of the arterioles.

[糖尿病微循环疾病静脉-动脉反应的发病机制及血流动力学意义]。
在人类糖尿病中,功能性微血管病变始于小静脉扩张,其原因尚不清楚。四氧嘧啶糖尿病动物的比较测量结果也证实了动-静脉口径关系的增加。生命显微镜下的研究表明,这些改变是由于小静脉充血和被动扩张导致的红细胞聚集和血液粘度增加。毛细血管后侧流动阻力的增加仅取决于流变学因素,而不取决于神经-体液因素,这是通过静脉-动脉对小动脉收缩增加的反应引起的。
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