Effect of intravenous infusion of OKY-1581 (Sodium-(E)-3-[4-(3-pyridylmethyl)phenyl]-2-methylacrylate) on circulatory thromboxane A2 and prostacyclin levels in anaesthetized baboon

Abstract

OKY-1581, a known inhibitor of thromboxane biosynthesis, was infused intravenously in six healthy baboons anaesthetized with pentobarbitone sodium. Systemic blood pressure and heart rate were continuously recorded and the levels of plasma thromboxane B₂ and 6-keto PGF_1α were determined in samples taken before, during and after the infusion of OKY-1581. Following the infusion of OKY-1581 plasma level of TXB₂ decreased and 6-keto PGF_1α level increased in most animals. However, these changes were not consistent or dose-related and no significant effect was seen in some animals.