Enhancement of rat renal allografts with various immunogens.

Abstract

Lewis rat recipients of Brown Norway (BN) and Dark Agouti (DA) kidneys were tested for enhanced survival after they were injected with various immunogens. Lewis recipients of BN kidneys injected with either BN whole blood, bone marrow cells, red blood cells, or DA whole blood had enhanced survival. Lewis recipients of BN kidneys injected with either BN plasma or BN thymocytes did not have enhanced survival. Lewis recipients of DN kidneys injected with DA blood had enhanced survival. Lymphocytotoxins were found infrequently in recipients with rejected renal allografts. Active enhancement of the rat renal graft may be produced by immunization with cells that express serum determined or cell determined antigens.