{"title":"The genetic and cellular basis of regulation of the immune response to tumor antigens.","authors":"M I Greene","doi":"10.1007/978-1-4684-3701-0_2","DOIUrl":null,"url":null,"abstract":"<p><p>In this chapter I have dealt with the cellular and genetic basis of regulation of the immune response to tumor antigen. I have knowingly omitted discussion of effectors such as ADCC, NK, and B cells, since my own experience with such effectors relates primarily to early events associated with small-tumor inocula (Greenberg and Greene, 1976). In that model, NK and ADCC mechanisms, in which natural antibody and macrophages participate, are of importance and T cells are not. In the studies I have dealt with herein, more advanced tumor models have been evaluated. It is clear, I hope, from this chapter that understanding the pathways to immune-cell or Ts activation will provide the basis for applied immunotherapy techniques in the future.</p>","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"72","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Contemporary topics in immunobiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/978-1-4684-3701-0_2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 72
Abstract
In this chapter I have dealt with the cellular and genetic basis of regulation of the immune response to tumor antigen. I have knowingly omitted discussion of effectors such as ADCC, NK, and B cells, since my own experience with such effectors relates primarily to early events associated with small-tumor inocula (Greenberg and Greene, 1976). In that model, NK and ADCC mechanisms, in which natural antibody and macrophages participate, are of importance and T cells are not. In the studies I have dealt with herein, more advanced tumor models have been evaluated. It is clear, I hope, from this chapter that understanding the pathways to immune-cell or Ts activation will provide the basis for applied immunotherapy techniques in the future.
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